Yes, and no. There is no magic forward all port 80 and 443 to this one box here silently. (I have tried to think of clean ways to do that, and have not come up with any yet.. If anyone has ideas...) But you can do things that can help. For on thing, almost everyone supports PAC files now. And almost everything supports Web Proxy Autodiscovery.
And an easy way to bring all of this together is the Captive Portal. If you set up captive portal (Place the proxy in allowed IPs.) you have a way to bypass the proxy if needed, and instrustions on how to use the proxy for everyeone else. Additionally, you have a web server on port 8000 to serve you PAC file for autodiscovery. Just make the login page simple so the instructions also show up in wegt, curl or fetch.